笔者回顾了“十一五”到“十四五”期间主持国家重点研发计划项目中课题组织和执行的历程,在原国家质检总局（后期为市场监管总局）组织领导和中国特种设备检测研究院牵头的特种设备安全科技研究发展战略中,笔者呈现了科研团队提出电站锅炉安全科技研究的总体技术思路、分析和综合相结合的研究方法,展示了协同科研取得的科研成果以及这些成果如何转化成指导电站锅炉安全生产促进经济和社会发展的安全监管体系、技术标准和安全评估及预测预警方法,为电站锅炉长周期安全运行构建了一道切实可行的防火墙。实践证明：体系化的领导组织管理、正确的研究思路和研究方法、实事求是反映时代需求的命题设置、产学研诸环节协同攻关创新、全面响应和解决电站锅炉安全生产中存在的现实问题是协同科技攻关重大需求研究中的成功路径。

This paper reviews the process of organizing and implementing the projects under the National Key R&D Program during the periods of the 11th Five-Year Plan through the 14th Five-Year Plan. Guided by the development strategy for special equipment safety technology research, which was led by the former General Administration of Quality Supervision, Inspection and Quarantine (later restructured into the State Administration for Market Regulation) and spearheaded by the China Special Equipment Inspection and Research Institute, the authors present the overall technical framework and the integrated analysis-synthesis research methodology proposed by the research team for utility boiler safety technology research. The paper demonstrates the scientific achievements yielded through collaborative research, and illustrates how these outcomes have been translated into safety supervision systems, technical standards, as well as safety assessment and prediction-warning methodologies. These implementations have guided the safe production of utility boilers, boosted economic and social development, and established a practical safeguard for the long-cycle safe operation of utility boilers. Practice has proven that the successful pathways for addressing major demands through collaborative scientific and technological research include: systematic organizational leadership and management, sound research philosophies and methodologies, the formulation of research topics that realistically reflect the needs of the times, collaborative innovation across industry, academia and research sectors, and comprehensive responses to practical problems in the safe production of utility boilers.